Gasch Lab

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All organisms must be able to sense and respond to their environment and defend themselves against environmental stress. We previously used DNA microarrays to examine the yeast response to environmental stresses and identified a large gene expression program, called the environmental stress response (ESR), that is activated by many types of stress. The ESR consists of ~1000 gene expression changes and includes ~600 repressed genes and ~350 induced genes.We are combining functional genomics and computational biology with traditional techniques in genetics, biochemistry, and molecular biology to understand the role, regulation, and evolution of the ESR.
Lab Website: http://gasch.genetics.wisc.edu/